Shane Crotty Selected Research

Transcription Factors (Transcription Factor)

1/2023	Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients.
8/2021	Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19.
1/2021	Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH).
3/2016	Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection.
10/2015	Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
2/2015	The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
10/2014	T follicular helper cell differentiation, function, and roles in disease.

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Shane Crotty Research Topics

Disease

45	Infections 11/2023 - 02/2002
25	COVID-19 11/2023 - 01/2020
15	Virus Diseases (Viral Diseases) 12/2023 - 02/2002
11	Smallpox (Variola) 11/2023 - 11/2003
10	Vaccinia 01/2017 - 01/2005
9	Communicable Diseases (Infectious Diseases) 01/2022 - 03/2004
8	Neoplasms (Cancer) 02/2024 - 02/2010
4	Mpox (monkeypox) 11/2023 - 10/2007
3	Autoimmune Diseases (Autoimmune Disease) 02/2024 - 01/2016
2	Hypersensitivity (Allergy) 02/2024 - 01/2019
2	Lung Injury 01/2023 - 01/2021
2	Reinfection 12/2022 - 01/2021
2	HIV Infections (HIV Infection) 12/2022 - 01/2016
2	Cytokine Release Syndrome 06/2021 - 04/2021
2	B-Cell Lymphoma (Lymphoma, B Cell) 01/2021 - 10/2014
2	Tuberculosis (Tuberculoses) 01/2020 - 01/2016
2	Atherosclerosis 01/2019 - 01/2018
2	Whooping Cough (Pertussis) 01/2018 - 06/2016
2	Tetanus 01/2018 - 01/2017
2	Inflammation (Inflammations) 10/2016 - 12/2008
2	Dengue (Dengue Fever) 01/2016 - 08/2015
2	Kaposi Varicelliform Eruption (Eczema Herpeticum) 01/2011 - 06/2009
2	Persistent Infection 01/2008 - 10/2006
2	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 01/2007 - 01/2006
1	Critical Illness (Critically Ill) 01/2023
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2023
1	Leukemia 01/2023
1	Pneumonia (Pneumonitis) 01/2023
1	Breakthrough Infections 01/2022
1	Human Influenza (Influenza) 01/2020
1	Tonsillitis 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2018
1	Melanoma (Melanoma, Malignant) 12/2017
1	Yellow Fever 01/2017
1	Bacterial Infections (Bacterial Infection) 01/2017
1	Lymphoma (Lymphomas) 10/2015
1	Neoplasm Metastasis (Metastasis) 10/2015
1	Ectromelia (Phocomelia) 09/2015
1	Severe Dengue 08/2015

Drug/Important Bio-Agent (IBA)

44	VaccinesIBA 11/2023 - 03/2004
17	Proteins (Proteins, Gene)FDA Link 11/2023 - 09/2005
17	AntigensIBA 01/2021 - 10/2004
15	EpitopesIBA 11/2023 - 07/2007
9	Smallpox Vaccine (Vaccine, Smallpox)FDA Link 11/2023 - 09/2005
9	Immunoglobulin G (IgG)IBA 01/2023 - 01/2003
8	Monoclonal AntibodiesIBA 11/2023 - 01/2010
7	Neutralizing AntibodiesIBA 10/2023 - 10/2006
7	Transcription Factors (Transcription Factor)IBA 01/2023 - 10/2014
7	COVID-19 VaccinesIBA 03/2022 - 01/2021
6	CytokinesIBA 02/2024 - 07/2007
6	AntibodiesIBA 09/2022 - 12/2009
4	ChromatinIBA 12/2023 - 01/2017
4	Broadly Neutralizing AntibodiesIBA 12/2022 - 01/2016
4	Antiviral Agents (Antivirals)IBA 12/2015 - 02/2002
4	Signaling Lymphocytic Activation Molecule Associated ProteinIBA 01/2007 - 01/2006
3	Messenger RNA (mRNA)IBA 11/2023 - 03/2021
3	Peptides (Polypeptides)IBA 03/2023 - 07/2007
3	N-(2-cyanoethylene)urea (BA 1)IBA 01/2023 - 03/2022
3	N-methyl-valyl-amiclenomycin (BA 2)IBA 01/2023 - 03/2022
3	Immunoglobulins (Immunoglobulin)IBA 01/2012 - 10/2004
3	ProteomeIBA 05/2007 - 01/2005
2	Interleukin-10 (Interleukin 10)IBA 02/2024 - 10/2006
2	bamlanivimabIBA 11/2023 - 12/2022
2	smallpox and monkeypox vaccine modified vaccinia ankara-bavarian nordicIBA 11/2023 - 03/2023
2	3- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- oneIBA 11/2023 - 03/2023
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 04/2023 - 02/2015
2	Histone MethyltransferasesIBA 04/2023 - 01/2023
2	mRNA VaccinesIBA 12/2022 - 01/2022
2	Angiotensin-Converting Enzyme 2IBA 01/2022 - 01/2021
2	Interleukin-15 (Interleukin 15)IBA 06/2021 - 04/2021
2	BNT162 VaccineIBA 03/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 10/2007
2	Viral VaccinesIBA 01/2018 - 01/2017
2	Tetanus Toxoid (Vaccine, Tetanus)FDA Link 01/2018 - 01/2017
2	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 08/2015 - 05/2010
2	Interleukin-6 (Interleukin 6)IBA 04/2013 - 03/2011
2	Immunoglobulin M (IgM)IBA 12/2009 - 10/2007
1	Interleukin-2 (IL2)IBA 02/2024
1	Interleukin-9 (Interleukin 9)IBA 02/2024
1	Therapeutic UsesIBA 11/2023
1	Viral RNAIBA 10/2023
1	histone H3 trimethyl Lys4IBA 04/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2023
1	AutoantibodiesIBA 01/2023
1	Small Interfering RNA (siRNA)IBA 01/2023
1	Immunoglobulin A (IgA)IBA 12/2022
1	NVX-CoV2373 adjuvated lipid nanoparticleIBA 10/2022
1	InterferonsIBA 10/2021
1	NucleotidesIBA 08/2021
1	AerosolsIBA 01/2021
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2018
1	HDL LipoproteinsIBA 01/2018
1	LuciferasesIBA 01/2017
1	Signaling Lymphocytic Activation Molecule FamilyIBA 03/2016
1	HLA-A Antigens (HLA-A)IBA 01/2016
1	Pertussis VaccineIBA 01/2016

Therapy/Procedure

6	Therapeutics 12/2022 - 01/2010
1	Phage Therapy 01/2023
1	Tonsillectomy 01/2019
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2017